Phenotypes Associated with This Genotype

Genotype
MGI:6358688

• Allelic Composition: Golga2^tm1.2Baos/Golga2^tm1.2Baos
• Genetic Background: B6.129(Cg)-Golga2^tm1.2Baos

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:272184 )

• die before P35

nervous system

decreased Purkinje cell number ( J:272184 )

• dramatic reduction in the number of Purkinje cells

cellular

abnormal Golgi apparatus morphology ( J:272184 )

• in MEFs

abnormal Golgi vesicle transport ( J:272184 )

• impaired secretory trafficking in MEFs

growth/size/body

decreased body weight ( J:272184 )

• significant reduction in body weight at P14, P21, and P28

slow postnatal weight gain ( J:272184 )

behavior/neurological

ataxia ( J:272184 )

• mice stagger and cannot stand steady on their hind legs