Phenotypes Associated with This Genotype

Genotype
MGI:6359782

• Allelic Composition: Pacc1^em1.1Zzq/Pacc1^em1.1Zzq
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased sensitivity to induced cell death ( J:273611 )

• at 12 days in vitro, primary cortical neurons are partially but significantly protected from delayed cell death induced by 1-hour acid treatment (pH 5.6 and pH 6.0)

nervous system

decreased susceptibility to ischemic brain injury ( J:273611 )

• 1 day after permanent middle cerebral artery occlusion (pMCAO), mice exhibit a significantly smaller total brain infarct volume and consistently improved neurological scores relative to similarly treated wild-type controls

decreased cerebral infarct size ( J:273611 )

• 1 day after pMCAO, mice exhibit a significantly smaller total brain infarct volume than similarly treated wild-type controls, as shown by triphenyltetrazolium chloride staining

abnormal neuron physiology ( J:273611 )

• at 12 days in vitro, primary cortical neurons completely lack proton-activated Cl^- (PAC) currents (I_Cl,H)

homeostasis/metabolism

decreased susceptibility to ischemic brain injury ( J:273611 )

• 1 day after permanent middle cerebral artery occlusion (pMCAO), mice exhibit a significantly smaller total brain infarct volume and consistently improved neurological scores relative to similarly treated wild-type controls

decreased cerebral infarct size ( J:273611 )

• 1 day after pMCAO, mice exhibit a significantly smaller total brain infarct volume than similarly treated wild-type controls, as shown by triphenyltetrazolium chloride staining