Phenotypes for Rhoa Rhpn1 Tg(NPHS2-cre)295Lbh MGI:6360618 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Rhoa^tm1Jrel/Rhoa^tm1Jrel Rhpn1^tm1Ktry/Rhpn1^tm1Ktry Tg(NPHS2-cre)295Lbh/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhoa^tm1Jrel mutation (0 available); any Rhoa mutation (73 available)
Rhpn1^tm1Ktry mutation (0 available); any Rhpn1 mutation (34 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:276466 )

• reduced body weight by 3 months of age

homeostasis/metabolism

increased circulating creatinine level ( J:276466 )

renal/urinary system

abnormal kidney morphology ( J:276466 )

• mice exhibit a more severe kidney injury than single Rhpn1 homozygotes

podocyte foot process effacement ( J:276466 )

• complete podocyte effacement

glomerulosclerosis ( J:276466 )

• segmental and global focal segmental glomerulosclerosis

renal interstitial fibrosis ( J:276466 )

dilated renal tubule ( J:276466 )

renal cast ( J:276466 )

• protein casts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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