Analysis Tools
mortality/aging
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• embryonic lethality at E10.5-E11.5
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growth/size/body
embryo
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• E10, but not E9, yolk sac shows aberrant blood vessel development
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cardiovascular system
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• cerebral blood vessels are truncated and exhibit disrupted organization instead of having a well-organized tree-like pattern
• cerebral blood vessels are highly dilated, being normal at E8.5 but becoming dilated by E9.5
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• cerebral blood vessels are truncated and exhibit disrupted organization instead of having a well-organized tree-like pattern
• the communicating artery is lost and disruption of major artery patterning is seen
• E10, but not E9, yolk sac shows aberrant blood vessel development
• however, no defect in cardiac development is seen and no obvious bronchial arch artery defects are seen
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• E10, but not E9, yolk sac shows aberrant blood vessel development
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nervous system
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• cerebral blood vessels are truncated and exhibit disrupted organization instead of having a well-organized tree-like pattern
• cerebral blood vessels are highly dilated, being normal at E8.5 but becoming dilated by E9.5
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