Phenotypes Associated with This Genotype

Genotype
MGI:6363017

• Allelic Composition: Plekho2^em1Lzhn/Plekho2^em1Lzhn
• Genetic Background: C57BL/6-Plekho2^em1Lzhn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:270531 )

N • macrophage exhibit normal differentiation and proliferation with normal LPS-induced macrophage activation

increased macrophage apoptosis ( J:270531 )

• of bone marrow-derived macrophage in the absence of M-CSF

decreased macrophage cell number ( J:270531 )

• F4/80^highCD11b+ macrophages in the spleen, blood and peritoneal cavity

• however, mice exhibit normal bone marrow-derived macrophages

cellular

increased macrophage apoptosis ( J:270531 )

• of bone marrow-derived macrophage in the absence of M-CSF

hematopoietic system

increased macrophage apoptosis ( J:270531 )

• of bone marrow-derived macrophage in the absence of M-CSF

decreased macrophage cell number ( J:270531 )

• F4/80^highCD11b+ macrophages in the spleen, blood and peritoneal cavity

• however, mice exhibit normal bone marrow-derived macrophages