Phenotypes Associated with This Genotype

Genotype
MGI:6363166

• Allelic Composition: Tg(TRAMP)8247Ng/0; Usp11^tm1Tac/Y
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland adenocarcinoma incidence ( J:270214 )

♂ • tumors progress to a highly penetrant invasive prostatic adenocarcinoma unlike in age-matched transgenic mice wild-type for Usp11

increased prostate intraepithelial neoplasia incidence ( J:270214 )

♂ • significantly higher rate of high grade prostatic intraepithelial neoplasia compared to transgenic mice wild-type for Usp11

increased metastatic potential ( J:270214 )

♂ • at 20 weeks of age tumor masses show severe malignant progression unlike in age-matched transgenic mice wild-type for Usp11

♂ • prostatic tumor nodules metastasize to lymph nodes at a higher rate compared to age-matched transgenic mice wild-type for Usp11

increased tumor growth/size ( J:270214 )

♂ • tumor masses are larger at 20 weeks of age compared to transgenic mice wild-type for Usp11

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:270214 )

♂ • tumors progress to a highly penetrant invasive prostatic adenocarcinoma unlike in age-matched transgenic mice wild-type for Usp11

increased prostate intraepithelial neoplasia incidence ( J:270214 )

♂ • significantly higher rate of high grade prostatic intraepithelial neoplasia compared to transgenic mice wild-type for Usp11

reproductive system

increased prostate gland adenocarcinoma incidence ( J:270214 )

♂ • tumors progress to a highly penetrant invasive prostatic adenocarcinoma unlike in age-matched transgenic mice wild-type for Usp11

increased prostate intraepithelial neoplasia incidence ( J:270214 )

♂ • significantly higher rate of high grade prostatic intraepithelial neoplasia compared to transgenic mice wild-type for Usp11