Phenotypes Associated with This Genotype

Genotype
MGI:6377559

• Allelic Composition: Ska2^{tm1b(KOMP)Wtsi}/Ska2^{tm1b(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Ska2^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0570_3_F06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• homozygous embryos are recovered at slightly lower Mendelian ratios at E7.5 (18% versus expected 25%) and arrest prior to gastrulation; no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5