Phenotypes Associated with This Genotype

Genotype
MGI:6377564

• Allelic Composition: Ccdc63^em1Osb/Ccdc63^em1Osb
• Genetic Background: involves: C57BL/6NJcl * DBA/2NJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:231237 )

♂ • no accessory structures are seen in spermatozoa, suggesting impaired formation of outer dense fibers, the mitochondrial sheath and the fibrous sheath

short sperm flagellum ( J:231237 )

♂ • shortened flagella

♂ • however, the 9 + 2 structure of the axoneme including the outer arm dynein is intact in spermatozoa

abnormal sperm head morphology ( J:231237 )

♂ • spermatozoa from the cauda epididymis show severe defects in sperm heads

asthenozoospermia ( J:231237 )

♂ • no motile spermatozoa are seen

abnormal spermiogenesis ( J:231237 )

♂ • spermatids show impaired development of flagella, lacking elongating flagella, although they have a developing acrosome

male infertility ( J:231237 )

♂ • males are infertile, producing no litters when mated with wild-type females

♂ • however, spermatozoa can activate oocytes with intracytoplasmic sperm injection

cellular

abnormal sperm flagellum morphology ( J:231237 )

♂ • no accessory structures are seen in spermatozoa, suggesting impaired formation of outer dense fibers, the mitochondrial sheath and the fibrous sheath

short sperm flagellum ( J:231237 )

♂ • shortened flagella

♂ • however, the 9 + 2 structure of the axoneme including the outer arm dynein is intact in spermatozoa

abnormal sperm head morphology ( J:231237 )

♂ • spermatozoa from the cauda epididymis show severe defects in sperm heads

asthenozoospermia ( J:231237 )

♂ • no motile spermatozoa are seen