Phenotypes Associated with This Genotype

Genotype
MGI:6381355

• Allelic Composition: Lpin1^fld/Lpin1^fld
• Genetic Background: involves: 129P2/OlaHsd * BALB/cByJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:220917 )

• both males and females are smaller

liver/biliary system

decreased liver triglyceride level ( J:220917 )

adipose tissue

abnormal fat pad morphology ( J:220917 )

• fat pad size is decreased

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:220917 )

N • mice exhibit normal blood chemistry, showing normal levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin, albumin, gamma-glutamyl transpeptidase, blood urea nitrogen, inorganic phosphorus, creatine kinase, cholesterol, total protein, glucose, and amylase

decreased triglyceride level ( J:220917 )

• mice retain 40-80% of wild-type triacylglycerol levels in adipose tissue indicating a small decrease

• triacylglycerol levels are decreased in spleen, kidney, and liver

decreased liver triglyceride level ( J:220917 )

abnormal enzyme/coenzyme activity ( J:220917 )

• phosphatidate phosphatase enzyme activity is reduced in adipose tissue

• phosphatidate phosphatase enzyme activity is also reduced in the spleen, kidney, liver, heart, skeletal muscle, brain and lung