Phenotypes for C3ar1 C5ar1 MGI:6382540 MGI Mouse

• apoptosis levels are increased in the retinas at 3 months and further increased at 14 months

• mice immunized with 4-HNE-adducted protein (HNE-MSA) show elevated cell apoptosis as indicated by elevated annexin V levels compared to wild-type mice

abnormal retina rod bipolar cell morphology ( J:214214 )

• density of rod bipolar cells is decreased at 3 months and declines further at 14 months of age

abnormal retina horizontal cell morphology ( J:214214 )

• density of horizontal cells is decreased

abnormal photoreceptor outer segment disc membrane morphology ( J:214214 )

• the normal structure of the outer segment discs is lost at 6 months of age

abnormal retina pigment epithelium morphology ( J:214214 )

• retinal pigment epithelium (RPE) cell nuclei are shrunken or apoptotic at 6 months

thin retina inner nuclear layer ( J:214214 )

• the inner nuclear layer is thinner at 3 and 14 months of age

thin retina outer nuclear layer ( J:214214 )

• outer nuclear layer thinning is seen at older ages

disorganized retina outer nuclear layer ( J:214214 )

• the outer nuclear layer is disorganized at 3 months of age

increased susceptibility to age-related retinal degeneration ( J:214214 )

• mice show progressive retinal cell loss

abnormal electroretinogram waveform feature ( J:214214 )

• the fast oscillation is reduced at 6 months of age

• mice immunized with 4-HNE-adducted protein (HNE-MSA) show a more severe reduction in ERG amplitude, however this phenotype is not related to immune responses as IL17-producting cells are diminished

decreased a-wave amplitude ( J:214214 )

• by 14 weeks of age, but not at 6 weeks, ERG a-waves are reduced and the reduction progresses with increasing age

decreased b-wave amplitude ( J:214214 )

• by 14 weeks of age, but not at 6 weeks, ERG b-waves are reduced and the reduction progresses with increasing age

abnormal c-wave shape ( J:214214 )

• the amplitude of the c-wave is reduced at 6 months of age

decreased circulating free fatty acids level ( J:214214 )

• plasma free polyunsaturdated fatty acid (linoleic acid and arachidonic acid) levels are decreased at 14 months of age

decreased circulating phospholipid level ( J:214214 )

• plasma lysophosphatidylcholine levels are decreased at 3 and 14 months of age

increased retina apoptosis ( J:214214 )