Phenotypes Associated with This Genotype

Genotype
MGI:6384268

• Allelic Composition: Msi1^tm1Okn/Msi1^tm1Okn
• Genetic Background: involves: C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:146380 )

• increase in the number of apoptotic cells in the outer nuclear layer indicating death of photoreceptors

short photoreceptor outer segment ( J:146380 )

• outer segments of rods are shorter along most of the retina

abnormal retina rod cell outer segment morphology ( J:146380 )

• rhodopsin-labeled membrane is sometimes scattered in the subretinal space indicating that rod outer segments are fragmented

retina photoreceptor degeneration ( J:146380 )

abnormal retina pigment epithelium morphology ( J:146380 )

• the visual cycle protein RPE65 is absent in the microvilli of retinal photoreceptor epithelium cells

• however, the morphology of the retinal pigment epithelium is preserved

thin retina outer nuclear layer ( J:146380 )

• the outer nuclear layer is a few cells thinner at 8 weeks of age, being 8-10 cells thick compared to 11-12 cells thick in wild-type mice

• the outer nuclear layer in the peripheral retina is 4-7 cells thick compared to 6-7 cells thick in controls

• total cell number within the outer nuclear layer throughout the retina is less than in controls

• however, the total number of cells within the inner nuclear layer and the ganglion cell layer are normal

cellular

increased retina apoptosis ( J:146380 )

• increase in the number of apoptotic cells in the outer nuclear layer indicating death of photoreceptors

nervous system

short photoreceptor outer segment ( J:146380 )

• outer segments of rods are shorter along most of the retina

abnormal retina rod cell outer segment morphology ( J:146380 )

• rhodopsin-labeled membrane is sometimes scattered in the subretinal space indicating that rod outer segments are fragmented

retina photoreceptor degeneration ( J:146380 )

pigmentation

abnormal retina pigment epithelium morphology ( J:146380 )

• the visual cycle protein RPE65 is absent in the microvilli of retinal photoreceptor epithelium cells

• however, the morphology of the retinal pigment epithelium is preserved