Phenotypes Associated with This Genotype

Genotype
MGI:6385521

• Allelic Composition: Yeats4^em1Zfa/Yeats4^em1Zfa; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal lymphopoiesis ( J:282740 )

• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients cause impaired differentiation of ILC1-ILC3s

• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced indicting that innate lymphoid cell (ILC) lineage commitment from the alpha4Beta7+ CLP stage is affected

• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed

• however, cell rates of long-term HSCs, short-term HSCs, and multipotent progenitors are unaffected and frequencies of common lymphoid progenitors (CLPs) and alpha4Beta7+ CLPs, myeloid progenitors, including common myeloid progenitors, granulocyte-macrophage progenitors, and megakaryocyte-erythrocyte progenitors are normal

decreased lymphocyte cell number ( J:282740 )

• decrease in group 1 innate lymphoid cells (ILC1s) in small intestinal intraepithelial lymphocytes and in the liver

• decrease in group 2 innate lymphoid cells (ILC2s) in the small intestine lamina propria and lungs

• decrease in group 3 innate lymphoid cells (ILC3s) is the small intestine lamina propria

• numbers of all innate lymphoid cell lineages are reduced

• numbers of ILC1s, ILC2s and ILC3s are decreased in small intestines of lethally irradiated CD45.1+ recipients transplanted with mutant CD45.2+ LSK cells

abnormal lymphocyte physiology ( J:282740 )

• IFN-gamma+ innate lymphoid cells are decreased in mesenteric lymph nodes of mice infected with Salmonella typhimurium

• total group 2 innate lymphoid cells (ILC2s) and IL-5 or IL-13 expressing ILC2s are reduced in the lungs upon intranasal administration of papain

• IL-22 producing group 3 innate lymphoid cells (ILC3s) are decreased in small intestines of Citrobacter rodentium infected mice

immune system

abnormal lymphopoiesis ( J:282740 )

• mutant common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients cause impaired differentiation of ILC1-ILC3s

• frequencies of alpha-lymphoid progenitors, common helper innate lymphoid cell progenitors (CHILPs), and innate lymphoid cell precursors (ILCPs) are reduced indicting that innate lymphoid cell (ILC) lineage commitment from the alpha4Beta7+ CLP stage is affected

• differentiation ability of alpha4Beta7+ CLPs in culture is suppressed

• however, cell rates of long-term HSCs, short-term HSCs, and multipotent progenitors are unaffected and frequencies of common lymphoid progenitors (CLPs) and alpha4Beta7+ CLPs, myeloid progenitors, including common myeloid progenitors, granulocyte-macrophage progenitors, and megakaryocyte-erythrocyte progenitors are normal

decreased lymphocyte cell number ( J:282740 )

• decrease in group 1 innate lymphoid cells (ILC1s) in small intestinal intraepithelial lymphocytes and in the liver

• decrease in group 2 innate lymphoid cells (ILC2s) in the small intestine lamina propria and lungs

• decrease in group 3 innate lymphoid cells (ILC3s) is the small intestine lamina propria

• numbers of all innate lymphoid cell lineages are reduced

• numbers of ILC1s, ILC2s and ILC3s are decreased in small intestines of lethally irradiated CD45.1+ recipients transplanted with mutant CD45.2+ LSK cells

abnormal lymphocyte physiology ( J:282740 )

• IFN-gamma+ innate lymphoid cells are decreased in mesenteric lymph nodes of mice infected with Salmonella typhimurium

• total group 2 innate lymphoid cells (ILC2s) and IL-5 or IL-13 expressing ILC2s are reduced in the lungs upon intranasal administration of papain

• IL-22 producing group 3 innate lymphoid cells (ILC3s) are decreased in small intestines of Citrobacter rodentium infected mice

abnormal gut-associated lymphoid tissue morphology ( J:282740 )

• numbers of intestinal lymphoid follicles are reduced

decreased Peyer's patch number ( J:282740 )

• numbers of Peyers patches are reduced

decreased interferon-gamma secretion ( J:282740 )

• group 1 innate lymphoid cells show impaired production of IFN-gamma in response to Salmonella typhimurium infection

abnormal interleukin secretion ( J:282740 )

• IL-22 secreted by ILC3s in lamina propria lymphocytes is reduced in Citrobacter rodentium infected mice

decreased interleukin-12 secretion ( J:282740 )

• concentration of IL-12 in bronchoalveolar lavage fluid is reduced when mice are administered papain

decreased interleukin-5 secretion ( J:282740 )

• concentration of IL-5 in bronchoalveolar lavage fluid is reduced when mice are administered papain

abnormal acute inflammation ( J:282740 )

• leukocyte infiltration is reduced in lungs upon treatment with papain

• eosinophil infiltration in bronchoalveolar lavage fluid and lungs is reduced upon treatment with papain

increased susceptibility to bacterial infection ( J:282740 )

• mice exhibit a higher number of Salmonella typhimurium CFUs in the mesenteric lymph nodes than controls

• mice exhibit increased susceptibility to Citrobacter rodentium infection, showing increased bacterial CFUs in feces and spleen, accelerated weight loss, shortened colon length and persistent intestinal damage