Phenotypes Associated with This Genotype

Genotype
MGI:6385529

• Allelic Composition: Lmo4^tm1Slp/Lmo4^tm1Slp; Yeats4^em1Zfa/Yeats4^em1Zfa; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal lymphopoiesis ( J:282740 )

• mutant alpha4Beta7+ common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)

• differentiation ability of alpha4Beta7+ CLPs in culture is impaired

abnormal lymphocyte physiology ( J:282740 )

• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection

• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge

immune system

abnormal lymphopoiesis ( J:282740 )

• mutant alpha4Beta7+ common lymphoid progenitors (CLPs) engrafted into Rag1/Il2rg null recipients produce fewer numbers of innate lymphoid cells (ILCs)

• differentiation ability of alpha4Beta7+ CLPs in culture is impaired

abnormal lymphocyte physiology ( J:282740 )

• mice exhibit a reduced number of IFN-gamma+ group 1 innate lymphoid cells (ILC1s) after S. typhimurium infection

• mice show a decreased number of group 2 innate lymphoid cells (ILC2s) in the lung and a reduced number of IL-5 and IL-13 secreting ILC2s in the lung after papain challenge

abnormal acute inflammation ( J:282740 )

• leukocyte infiltration is attenuated in the lungs after papain challenge

increased susceptibility to bacterial infection ( J:282740 )

• mice exhibit a higher number of S. typhimurium CFUs in mesenteric lymph nodes after infection than controls

• mice exhibit a higher number of bacterial CFUs in feces, weight loss and shrinking colon length accompanied by more severe intestinal damage after C. rodentium infection