Analysis Tools
mortality/aging
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• nearly all mice are moribund by 4 days post intranasal infection with 2.3x10^4 P.F.U. of SARS-CoV
• lethality is also seen after infection with 2.3x10^3 or 2.3x10^2 P.F.U.
• the 50% lethal dose for SARS-CoV in these mice is less than 230 P.F.U.
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immune system
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• begin to lose weight by 3 to 5 days after infection with the Urbani strain of SARS-CoV
• concomitant with weight loss mice become lethargic and develop breathing difficulties
• viral titers in the lungs are 5 to 10-fold higher at 2 days post infection with SARS-Cov compared to non-transgenic littermates
• SARS-CoV is detectable in the brain of line 2 mice at 2 and 3 days but not 1 day post infection in comparison virus is not detectable in the brain until 9 days post infection in non-transgenic littermates
• inflammatory responses and signs of lung injury are increased at 2 days post infection compared to non-transgenic littermates
• at 4 days post infection non-transgenic littermates show resolution of most inflammatory responses, in contrast transgenic mice show perivascular and peribronchial inflammation, hemorrhage, and congestion of alveolar septa
• patchy, intense neutrophilic infiltrates are seen in the lungs of some mice
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• nearly all mice are moribund by 4 days post intranasal infection with 2.3x10^4 P.F.U. of SARS-CoV
• lethality is also seen after infection with 2.3x10^3 or 2.3x10^2 P.F.U.
• the 50% lethal dose for SARS-CoV in these mice is less than 230 P.F.U.
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respiratory system
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• at 4 days post infection with 2.3x10^4 P.F.U. of SARS-CoV
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cardiovascular system
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• at 4 days post infection with 2.3x10^4 P.F.U. of SARS-CoV
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| severe acute respiratory syndrome | DOID:2945 | J:283648 | ||
