Phenotypes Associated with This Genotype

Genotype
MGI:6402445

• Allelic Composition: Tg(CAG-DPP4)4Yuzh/0
• Genetic Background: C57BL/6-Tg(CAG-DPP4)4Yuzh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:286175 )

• mice infected with the EMC2012 strain of Middle East respiratory coronavirus (MERS-CoV) all die by day 10 post infection

immune system

abnormal spleen morphology ( J:286175 )

• spleen of MERS-CoV-infected mice shows necrosis of splenic cells and increased reticulum cells in red pulp with hemosiderin deposition at 5 and 9 dpi

abnormal circulating cytokine level ( J:286175 )

• MERS-CoV-infected mice show an increase in cytokines such as IFN-gamma, IP-10, and IL-17 in the serum on 5 dpi

increased circulating interferon-gamma level ( J:286175 )

• serum IFN-gamma levels are increased at 5 dpi with MERS-CoV

increased circulating interleukin-17 level ( J:286175 )

• serum IL-17 levels are increased at 5 dpi with MERS-CoV

brain inflammation ( J:286175 )

• MERS-CoV-infected mice show characteristics of viral encephalitis in the brain at 9 dpi, with perivascular cuffs and neuronal cell necrosis in the cerebral cortex

liver inflammation ( J:286175 )

• MERS-CoV-infected mice show mild to moderate liver damage on 5 dpi, including scattered hepatocyte necrosis and numerous activated Kupffer cells and macrophage infiltrates in hepatic sinusoid and by 9 dpi, fatty change in hepatocytes with less necrosis is seen

kidney inflammation ( J:286175 )

• MERS-CoV-infected mice show mild interstital inflammation in the kidneys with inflammatory cell infiltration in the interstitium and exudates of renal tubules on 5 dpi and increased renal tubular epithelial cell injury with focal hemorrhage in the renal interstitium by 9 dpi

lung inflammation ( J:286175 )

• MERS-CoV-infected mice show mild inflammation in the lungs with focal exudation and hemorrhage at 5 days post infection (dpi), and more severe damage with diffused alveolar damage, alveolar septal thickening, hemorrhage, and activated macrophage infiltration at 9 dpi

increased susceptibility to Coronaviridae infection ( J:286175 )

• mice infected with the EMC2012 strain of Middle East respiratory coronavirus (MERS-CoV) exhibit decreased activity and weigh less from day 6 after infection and die by 10 days post infection (dpi)

• type I and type II pneumocytes in the lungs, tubular epithelial cells in the kidneys, and neuronal cell bodies, dendrites, axons, and some microglia in the cerebral cortex, including the hippocampus, express viral antigen

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:286175 )

• mice infected with the EMC2012 strain of Middle East respiratory coronavirus (MERS-CoV) all die by day 10 post infection

respiratory system

lung hemorrhage ( J:286175 )

• lungs show hemorrhage at 5 dpi with MERS-CoV

lung inflammation ( J:286175 )

• MERS-CoV-infected mice show mild inflammation in the lungs with focal exudation and hemorrhage at 5 days post infection (dpi), and more severe damage with diffused alveolar damage, alveolar septal thickening, hemorrhage, and activated macrophage infiltration at 9 dpi

behavior/neurological

paralysis ( J:286175 )

• MERS-CoV infected mice show symptoms of neural defects with paralysis on day 9 after infection

cardiovascular system

lung hemorrhage ( J:286175 )

• lungs show hemorrhage at 5 dpi with MERS-CoV

kidney hemorrhage ( J:286175 )

• focal hemorrhage in the renal interstitium is seen at 9 dpi with MERS-CoV

hematopoietic system

abnormal spleen morphology ( J:286175 )

• spleen of MERS-CoV-infected mice shows necrosis of splenic cells and increased reticulum cells in red pulp with hemosiderin deposition at 5 and 9 dpi

homeostasis/metabolism

abnormal circulating cytokine level ( J:286175 )

• MERS-CoV-infected mice show an increase in cytokines such as IFN-gamma, IP-10, and IL-17 in the serum on 5 dpi

increased circulating interferon-gamma level ( J:286175 )

• serum IFN-gamma levels are increased at 5 dpi with MERS-CoV

increased circulating interleukin-17 level ( J:286175 )

• serum IL-17 levels are increased at 5 dpi with MERS-CoV

liver/biliary system

liver inflammation ( J:286175 )

• MERS-CoV-infected mice show mild to moderate liver damage on 5 dpi, including scattered hepatocyte necrosis and numerous activated Kupffer cells and macrophage infiltrates in hepatic sinusoid and by 9 dpi, fatty change in hepatocytes with less necrosis is seen

nervous system

brain inflammation ( J:286175 )

• MERS-CoV-infected mice show characteristics of viral encephalitis in the brain at 9 dpi, with perivascular cuffs and neuronal cell necrosis in the cerebral cortex

renal/urinary system

kidney hemorrhage ( J:286175 )

• focal hemorrhage in the renal interstitium is seen at 9 dpi with MERS-CoV

kidney inflammation ( J:286175 )

• MERS-CoV-infected mice show mild interstital inflammation in the kidneys with inflammatory cell infiltration in the interstitium and exudates of renal tubules on 5 dpi and increased renal tubular epithelial cell injury with focal hemorrhage in the renal interstitium by 9 dpi

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Middle East respiratory syndrome		DOID:0080642		J:286175