About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6402915
Allelic
Composition		 Ace2tm1Pngr/Ace2tm1Pngr
Genetic
Background		 B6.129P2-Ace2tm1Pngr/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2tm1Pngr mutation (1 available); any Ace2 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to Coronaviridae infection ( J:286299 )
• mice show decreased susceptibility to intranasal infection with severe acute respiratory syndrome coronavirus (SARS-CoV; Beijing strain, PUMC01 isolate) , showing lower levels of infectious virus in the lungs, reduced copy numbers of the SARS-CoV Spike RNA, and reduced pathologic alterations in lungs compared to infected wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory