Phenotypes Associated with This Genotype

Genotype
MGI:6403269

• Allelic Composition: Uqcrc1^tm1Zzuo/Uqcrc1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:285933 )

• less time spent with novel object

• time to find target on test day 4 in Barnes maze test significantly less reduced than wildtype

• longer time to identify target 1 and 8 days after testing in Barnes maze test

• normal behavior in open field test

impaired spatial learning ( J:285933 )

• time to find target on test day 4 in Barnes maze test significantly less reduced than wildtype

• longer time to identify target 1 and 8 days after testing in Barnes maze test

abnormal response to novel object ( J:285933 )

• less time spent with novel object

nervous system

increased susceptibility to ischemic brain injury ( J:285933 )

• larger infarct brain volume after brain hypoxia

• poorer neurological deficit score after brain hypoxia or middle cerebral arterial occlusion (MCAO)

growth/size/body

growth/size/body region phenotype ( J:285933 )

N • normal appearance

N • normal body weight at age 3 months

N • normal sex-specific body weight gain with age

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:285933 )

• larger infarct brain volume after brain hypoxia

• poorer neurological deficit score after brain hypoxia or middle cerebral arterial occlusion (MCAO)

cardiovascular system

cardiovascular system phenotype ( J:285933 )

N • normal heart rate and mean arterial blood pressure

reproductive system

reproductive system phenotype ( J:285933 )

N • fertile