Phenotypes Associated with This Genotype

Genotype
MGI:6403447

• Allelic Composition: Gt(ROSA)26Sor^{em1(DPP4)Yowa}/Gt(ROSA)26Sor^{em1(DPP4)Yowa}
• Genetic Background: C57BL/6-Gt(ROSA)26Sor^{em1(DPP4)Yowa}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Coronaviridae infection ( J:279060 )

• mice are susceptible to infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) strain hCoV-EMC , showing up to 28% weight loss by 5 days post infection (dpi), significant viral titers in the lungs and in the brain, and severe lung disease related to acute respiratory symptoms

• however, no lesions or viral titers are seen in the liver and kidney

• mice treated with a MERS-CoV S-RBD-specific neutralizing antibody (H111-1) are protected from challenge with MERS-CoV, showing decreased viral titers in lungs and reduced weight loss

• mice are also susceptible to infection with high-titer of an optimized pseudotyped MERS-CoV, with younger mice more susceptible than older mice

nervous system

gliosis ( J:279060 )

• MERS-CoV-infected mice exhibit perivascular gliosis in the cerebellum, cerebral ganglia and cerebrum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Middle East respiratory syndrome		DOID:0080642		J:279060