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Phenotypes Associated with This Genotype
Genotype
MGI:6403489
Allelic
Composition		 Tlr3tm1Aki/Tlr3tm1Aki
Tlr7tm1Aki/Tlr7tm1Aki
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr3tm1Aki mutation (2 available); any Tlr3 mutation (68 available)
Tlr7tm1Aki mutation (3 available); any Tlr7 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interferon-alpha secretion ( J:144400 )
• bone marrow-derived plasmacytoid dendritic cells infected with a low dose of murine hepatitis virus A59 are not able to produce IFN-alpha compared to wild-type mice that show IFN-alpha production

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory