Phenotypes Associated with This Genotype

Genotype
MGI:6404053

• Allelic Composition: Tg(KRT5-cre)1Tak/Tg(KRT5-cre)1Tak
• Genetic Background: involves: C3H * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal mammary gland epithelium morphology ( J:120797 )

• low squamous instead of the normal cuboidal to columnar forms during lactation

abnormal mammary gland duct morphology ( J:120797 )

• decreased number of ducts

abnormal branching of the mammary ductal tree ( J:120797 )

• decreased secondary and tertiary branches in virgin mice

abnormal lactation ( J:120797 )

abnormal mammary gland epithelium physiology ( J:120797 )

• increased quiescent alveolus epithelial cells during lactation compared with control mice

• secretory defect during lactation

abnormal coat appearance ( J:120797 )

• wavy and short coat

alopecia ( J:120797 )

• patches over time

waved hair ( J:120797 )

• at 11 days

• less pronounced after 6 to 8 weeks

abnormal hair follicle development ( J:120797 )

• observed starting at day 9 and more evident at day 14

• misaligned and variable angled follicles

enlarged hair follicles ( J:120797 )

• spanning the entire thickness of the dermal layer

curly vibrissae ( J:120797 )

• shortly after birth and more prominent in adulthood

cellular

cellular phenotype ( J:120797 )

N • mammary cells exhibit normal genomic stability

maternal effect ( J:120797 )

• some pups of homozygous dams die after birth without milk spots and surviving pups are runted due to impaired lactation

behavior/neurological

absent gastric milk in neonates ( J:120797 )

• in pups of homozygous dams

endocrine/exocrine glands

abnormal mammary gland epithelium morphology ( J:120797 )

• low squamous instead of the normal cuboidal to columnar forms during lactation

abnormal mammary gland duct morphology ( J:120797 )

• decreased number of ducts

abnormal branching of the mammary ductal tree ( J:120797 )

• decreased secondary and tertiary branches in virgin mice

abnormal lactation ( J:120797 )

abnormal mammary gland epithelium physiology ( J:120797 )

• increased quiescent alveolus epithelial cells during lactation compared with control mice

• secretory defect during lactation