Phenotypes Associated with This Genotype

Genotype
MGI:6408241

• Allelic Composition: Ap2s1^em1(IMPC)Tcp/Ap2s1^em1(IMPC)Tcp
• Genetic Background: C57BL/6NCrl-Ap2s1^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Ap2s1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ap2s1^em1(IMPC)Tcp/Ap2s1^em1(IMPC)Tcp embryos are arrested prior to gastrulation with embryos recovered at E7.5 but not at E9.5. Embryos at E7.5 are smaller, without the presence of head folds, primitive node or primitive streak formation.

embryo

failure to gastrulate ( J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

decreased egg cylinder size ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E7.5 (10% versus expected 25%, n=39) and arrest prior to gastrulation; no homozygous embryos are recovered at E9.5