Phenotypes Associated with This Genotype

Genotype
MGI:6414961

• Allelic Composition: Acvr1^tm1Mak/Acvr1⁺; Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; H3c2^tm1Mak/H3c2⁺; Olig2^{tm1.1(cre)Wdr}/Olig2⁺
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased brain tumor incidence ( J:285841 )

• most mice succumb to spontaneous brain tumors, with a median survival of 419 days

increased glioma incidence ( J:285841 )

• tumors are high-grade diffuse gliomas

• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions

• tumors express markers of oligodendroglial origin

nervous system

increased brain tumor incidence ( J:285841 )

• most mice succumb to spontaneous brain tumors, with a median survival of 419 days

increased glioma incidence ( J:285841 )

• tumors are high-grade diffuse gliomas

• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions

• tumors express markers of oligodendroglial origin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
brain glioma		DOID:0060108		J:285841