Phenotypes Associated with This Genotype

Genotype
MGI:6415589

• Allelic Composition: Tg(Adipoq-Zc3h10)#Hsul/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown fat cell morphology ( J:287066 )

♂ • increase in the number of mitochondria in males

abnormal brown adipose tissue physiology ( J:287066 )

♂ • oxygen consumption is increased in isolated brown adipose tissue from males

abnormal brown adipose tissue thermogenesis ( J:287066 )

♂ • after 4 h of cold exposure brown adipose tissue temperature is increased compared to wild-type controls in males

abnormal white adipose tissue physiology ( J:287066 )

♂ • oxygen consumption is increased in isolated inguinal white adipose tissue from males

growth/size/body

decreased susceptibility to diet-induced obesity ( J:287066 )

♂ • males are significantly leaner after 5 and 8 weeks on a high fat diet with smaller white adipose depots

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:287066 )

♂ • males are significantly leaner after 5 and 8 weeks on a high fat diet with smaller white adipose depots

decreased susceptibility to induced hypothermia ( J:287066 )

♂ • after 2 or 4 h of cold exposure body temperature is 2 and 5 degrees C higher than in similarly treated controls in males

increased oxygen consumption ( J:287066 )

♂ • in both ambient and cold temperature conditions without changes in food consumption or locomotor activity in males

♂ • oxygen consumption is increased in both isolated brown and inguinal white adipose tissue in males

improved glucose tolerance ( J:287066 )

♂ • in male mice on a high fat diet compared to diet matched wild-type controls

increased insulin sensitivity ( J:287066 )

♂ • in male mice on a high fat diet compared to diet matched wild-type controls

cellular

increased mitochondrial number ( J:287066 )

♂ • increased in brown adipose tissue in males