Phenotypes Associated with This Genotype

Genotype
MGI:6416300

• Allelic Composition: Anxa3^{tm1c(EUCOMM)Hmgu}/Anxa3^{tm1c(EUCOMM)Hmgu}; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina blood vessel morphology ( J:287184 )

• retinas with multiple artery-vein crossovers often display bifurcated veins

• retinal vein diameters, but not artery diameters, are slightly increased

• however, mice show no morphological defects in the developing vasculature at E9.5 and no angiogenic defects are seen in P7 retinas

abnormal retina blood vessel pattern ( J:287184 )

• 62.5% of mice exhibit artery-vein alignment defects in P7 retinas, with retinas displaying atypical artery-vein crossovers instead of running parallel to each other, and a few retinas having multiple artery-vein crossovers

• retinal artery-vein crossovers persist into adulthood with 58% of retinas showing crossovers in 4- to 9-month old mice

• artery-vein misalignments happen in all areas of the retina, including both proximal and distal to the optic nerve

• however, blood vessels associated with artery-vein crossovers show no occlusion

vision/eye

abnormal retina blood vessel morphology ( J:287184 )

• retinas with multiple artery-vein crossovers often display bifurcated veins

• retinal vein diameters, but not artery diameters, are slightly increased

• however, mice show no morphological defects in the developing vasculature at E9.5 and no angiogenic defects are seen in P7 retinas

abnormal retina blood vessel pattern ( J:287184 )

• 62.5% of mice exhibit artery-vein alignment defects in P7 retinas, with retinas displaying atypical artery-vein crossovers instead of running parallel to each other, and a few retinas having multiple artery-vein crossovers

• retinal artery-vein crossovers persist into adulthood with 58% of retinas showing crossovers in 4- to 9-month old mice

• artery-vein misalignments happen in all areas of the retina, including both proximal and distal to the optic nerve

• however, blood vessels associated with artery-vein crossovers show no occlusion