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Phenotypes Associated with This Genotype
Genotype
MGI:6433775
Allelic
Composition		 Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Tnfrsf1btm1Imx/Tnfrsf1btm1Imx
Genetic
Background		 B6.129S-Tnfrsf1btm1Imx Tnfrsf1atm1Imx/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Imx mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1btm1Imx mutation (5 available); any Tnfrsf1b mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to Coronaviridae infection ( J:288523 )
• mice infected with mouse-adapted SARS-CoV MA15 exhibit protection from weight loss that is seen in wild-type mice and decreased viral titers

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory