Analysis Tools
immune system
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• lungs of mice infected with a high dose of MERS-CoV are infiltrated with neutrophils; neutrophils infiltrate up to 4 dpi then return to normal levels
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• lungs of mice infected with a high dose of MERS-CoV are infiltrated with CD4+ T cells over the course of infection; CD4+ T cells infiltrate after 4 dpi and reach high levels by 7 dpi
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• lungs of mice infected with a high dose of MERS-CoV are infiltrated with CD8+ T cells over the course of infection; CD8+T cells infiltrate after 4 dpi and reach high levels by 7 dpi
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• lungs of mice infected with a high dose of MERS-CoV are infiltrated with macrophages over the course of infection; macrophages infiltrate after 4 dpi and remain at high levels by 7 dpi
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• mice infected with MERS-CoV show lymphocytic perivascular inflammation, macrophage infiltration, and pleuritis
• mice infected with the intermediate dose of MERS-CoV resolve all signs of disease including lymphocytic perivascular inflammation by 14 dpi while mice infected with the low dose still show lymphocytic perivascular inflammation through 21 dpi but resolve all other inflammatory parameters by 14 dpi
• lungs of mice infected with a high dose of MERS-CoV are infiltrated with macrophages, neutrophils, and CD4+ and CD8+ T cells over the course of infection
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• mice infected with a high dose of MERS-CoV-Hu/Jordan-N3/2012
• mice infected with an intermediate dose of MERS-CoV intranasally lose 10% of body weight by 7 dpi but regain 5% of starting body weight by 8 dpi and remain at 100% of starting body weight from 9 dpi and show no other signs of disease
• mice infected with a low dose of MERS-CoV intranasally do not lose weight and show no signs of disease
• mice infected with the high dose of MERS-CoV show viral RNA in the lungs, blood and spleen, but not in the brain, liver, or kidney
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respiratory system
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• mice infected with the high dose of MERS-CoV show moderate lung edema by 7 dpi
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• mice infected with MERS-CoV show lymphocytic perivascular inflammation, macrophage infiltration, and pleuritis
• mice infected with the intermediate dose of MERS-CoV resolve all signs of disease including lymphocytic perivascular inflammation by 14 dpi while mice infected with the low dose still show lymphocytic perivascular inflammation through 21 dpi but resolve all other inflammatory parameters by 14 dpi
• lungs of mice infected with a high dose of MERS-CoV are infiltrated with macrophages, neutrophils, and CD4+ and CD8+ T cells over the course of infection
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• mice infected with MERS-CoV Jordan show epithelial necrosis
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homeostasis/metabolism
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• mice infected with the high dose of MERS-CoV show moderate lung edema by 7 dpi
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hematopoietic system
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• lungs of mice infected with a high dose of MERS-CoV are infiltrated with neutrophils; neutrophils infiltrate up to 4 dpi then return to normal levels
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• lungs of mice infected with a high dose of MERS-CoV are infiltrated with CD4+ T cells over the course of infection; CD4+ T cells infiltrate after 4 dpi and reach high levels by 7 dpi
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• lungs of mice infected with a high dose of MERS-CoV are infiltrated with CD8+ T cells over the course of infection; CD8+T cells infiltrate after 4 dpi and reach high levels by 7 dpi
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• lungs of mice infected with a high dose of MERS-CoV are infiltrated with macrophages over the course of infection; macrophages infiltrate after 4 dpi and remain at high levels by 7 dpi
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Middle East respiratory syndrome | DOID:0080642 | J:238079 | ||
