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Phenotypes Associated with This Genotype
Genotype
MGI:6449115
Allelic
Composition		 Ace2em1Shyy/Ace2em1Shyy
Genetic
Background		 B6.Cg-Ace2em1Shyy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ace2em1Shyy mutation (0 available); any Ace2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
pulmonary hypertension ( J:286356 )
• mice subjected to SU5416/hypoxia-reoxygenation show aggravated pulmonary hypertension compared to controls, characterized by elevated right ventricular systolic pressure, increased Fulton index, vascular blushing of small pulmonary arteries, and aggravated vasculature

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory