Phenotypes Associated with This Genotype

Genotype
MGI:6449667

• Allelic Composition: Ifnar1^tm1Agt/Ifnar1^tm1Agt
• Genetic Background: involves: 129S2/SvPas * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:291874 )

• all mice infected with murine hepatitis virus strain 1 (MHV-1) succumb to a sub-lethal dose compared to only about 10% of control BALB/c mice

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:291874 )

• mice infected with the mouse-adapted H1N1 influenza A virus, PR8 strain, succumb to a sub-lethal dose compared to only about 20% of control BALB/c mice

immune system

decreased T cell apoptosis ( J:291874 )

• SARS-CoV-MA15-infected mice show lower levels of CD8 and CD4 T cell apoptos

increased CD4-positive, alpha-beta T cell number ( J:291874 )

• SARS-CoV-MA15-infected mice show increased numbers of virus-specific CD4 T cells in lungs

increased CD8-positive, alpha-beta T cell number ( J:291874 )

• SARS-CoV-MA15-infected mice show increased numbers of virus-specific CD8 T cells in lungs

abnormal mononuclear phagocyte morphology ( J:291874 )

• SARS-CoV-MA15-infected mice do show an increase in highly activated inflammatory monocyte-macrophages as is seen in infected BALB/c controls

• SARS-CoV-MA15-infected mice show a decrease in the percentage and numbers of inflammatory monocyte-macrophages that produce the pro-inflammatory cytokines TNF, IL-6, IL1-beta, and iNOS

decreased Ly6C high monocyte number ( J:291874 )

• SARS-CoV-MA15-infected mice do not show an increase in Ly6C^hiCD11b⁺ cells in the lungs as is seen in controls

abnormal cytokine level ( J:291874 )

• SARS-CoV-MA15- infected mice have reduced levels of cytokines and chemokines in the broncho-alveolar lavage fluid

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:291874 )

• all mice infected with murine hepatitis virus strain 1 (MHV-1) succumb to a sub-lethal dose compared to only about 10% of control BALB/c mice

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:291874 )

• mice infected with the mouse-adapted H1N1 influenza A virus, PR8 strain, succumb to a sub-lethal dose compared to only about 20% of control BALB/c mice

decreased susceptibility to Coronaviridae infection ( J:291874 )

• mice infected with a lethal dose of the mouse adapted severe acute respiratory syndrome coronavirus (SARS-CoV-MA15) survive the infection, exhibiting only a moderate 15% weight loss and mild to moderate clinical disease

• middle-aged (8-9 month old) mice show increased survival after SARS-CoV-MA15 infection compared to middle-aged BALB/c control mice

• total lung virus loads after SARS-CoV-MA15 infection are the same as in control mice, except for a modest increase at 3 days post infection (dpi) in mutants

• SARS-CoV-MA15 virus is completely cleared from the lungs by 10 dpi

• SARS-CoV-MA15-infected mice show nearly normal lungs at 3 and 5 dpi compared to hyperemia and congestion in controls, with minimal alveolar edema and increased peribronchial-perivascular immune cell infiltration, and reduced lung microvascular leakage

homeostasis/metabolism

abnormal cytokine level ( J:291874 )

• SARS-CoV-MA15- infected mice have reduced levels of cytokines and chemokines in the broncho-alveolar lavage fluid

hematopoietic system

decreased T cell apoptosis ( J:291874 )

• SARS-CoV-MA15-infected mice show lower levels of CD8 and CD4 T cell apoptos

increased CD4-positive, alpha-beta T cell number ( J:291874 )

• SARS-CoV-MA15-infected mice show increased numbers of virus-specific CD4 T cells in lungs

increased CD8-positive, alpha-beta T cell number ( J:291874 )

• SARS-CoV-MA15-infected mice show increased numbers of virus-specific CD8 T cells in lungs

abnormal mononuclear phagocyte morphology ( J:291874 )

• SARS-CoV-MA15-infected mice do show an increase in highly activated inflammatory monocyte-macrophages as is seen in infected BALB/c controls

• SARS-CoV-MA15-infected mice show a decrease in the percentage and numbers of inflammatory monocyte-macrophages that produce the pro-inflammatory cytokines TNF, IL-6, IL1-beta, and iNOS

decreased Ly6C high monocyte number ( J:291874 )

• SARS-CoV-MA15-infected mice do not show an increase in Ly6C^hiCD11b⁺ cells in the lungs as is seen in controls

cellular

decreased T cell apoptosis ( J:291874 )

• SARS-CoV-MA15-infected mice show lower levels of CD8 and CD4 T cell apoptos