Phenotypes Associated with This Genotype

Genotype
MGI:6455521

• Allelic Composition: Coq8b^{tm1c(EUCOMM)Hmgu}/Coq8b^{tm1c(EUCOMM)Hmgu}; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hunched posture ( J:294296 )

• from age 9 months

cellular

increased mitochondrial number ( J:294296 )

• in glomerular podocytes as mice age 10 months

increased mitochondrial size ( J:294296 )

• in glomerular podocytes as mice age 10 months

homeostasis/metabolism

increased blood urea nitrogen level ( J:294296 )

• from age 7 months

• increase in creatinine-albumin ratio from age 5 months

decreased circulating serum albumin level ( J:294296 )

• from age 5 months

• increase in creatinine-albumin ratio from age 5 months

increased circulating serum albumin level ( J:294296 )

• increase in creatinine-albumin ratio from age 5 months

integument

abnormal coat appearance ( J:294296 )

• seedy fur from age 9 months

mortality/aging

premature death ( J:294296 )

• from age 9 months

renal/urinary system

abnormal podocyte morphology ( J:294296 )

• at age 10 months

podocyte foot process effacement ( J:294296 )

• at age 10 months

abnormal podocyte slit junction morphology ( J:294296 )

• significantly reduced number of filtration-slit units per micrometer of basement membrane at age 10 months

glomerulosclerosis ( J:294296 )

• global and focal segmental glomerulosclerosis at age 10 months

renal interstitial fibrosis ( J:294296 )

• at age 10 months

small kidney ( J:294296 )

• at age 10 months

renal tubule atrophy ( J:294296 )

• at age 10 months

pale kidney ( J:294296 )

• at age 10 months

kidney failure ( J:294296 )