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Phenotypes Associated with This Genotype
Genotype
MGI:6458049
Allelic
Composition		 Lama2tm1Eeng/Lama2tm1Eeng
Smdt1tm1c(EUCOMM)Wtsi/Smdt1tm1c(EUCOMM)Wtsi
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama2tm1Eeng mutation (2 available); any Lama2 mutation (177 available)
Smdt1tm1c(EUCOMM)Wtsi mutation (0 available); any Smdt1 mutation (11 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:287405 )
• as in Lama2tm1Eeng homozygotes

behavior/neurological
decreased grip strength ( J:287405 )
• as in Lama2tm1Eeng homozygotes

cellular
abnormal mitochondrial physiology ( J:287405 )
• increase in mitochondrial calcium in skeletal muscle fiber as in Lama2tm1Eeng homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory