Phenotypes Associated with This Genotype

Genotype
MGI:6488563

• Allelic Composition: Adam28^tm1.2Dica/Adam28^tm1.2Dica
• Genetic Background: B6JRj.129-Adam28^tm1.2Dica

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of induced tumors ( J:298188 )

• increased tumor density in lungs after injection of LLC or B16K1 tumor cells

• normal tumor proliferation and apoptosis rates in lungs after injection of LLC tumor cells

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:298188 )

• decreased survival owing to increased metastatic pulmonary colonization after injection of LLC tumor cells

hematopoietic system

abnormal lymphocyte morphology ( J:298188 )

• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells

• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice

• normal pulmonary infiltration of CD4+ CD3+ T cells, Treg cells and B cells 21 days after injection of LLC tumor cells

• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice

• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice

• normal CD8+ T cell activation, proliferation and migration in lungs and spleen after injection of LLC tumor cells

abnormal alpha-beta T cell morphology ( J:298188 )

• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells

• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice

• normal pulmonary infiltration of CD4+ CD3+ T cells and Treg cells 21 days after injection of LLC tumor cells

• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice

• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice

• normal CD8+ T cell activation, proliferation and migration in lungs and spleen after injection of LLC tumor cells

decreased CD8-positive, alpha-beta T cell number ( J:298188 )

• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells

• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice

• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice

• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice

immune system

abnormal lymphocyte morphology ( J:298188 )

• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells

• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice

• normal pulmonary infiltration of CD4+ CD3+ T cells, Treg cells and B cells 21 days after injection of LLC tumor cells

• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice

• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice

• normal CD8+ T cell activation, proliferation and migration in lungs and spleen after injection of LLC tumor cells

abnormal alpha-beta T cell morphology ( J:298188 )

• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells

• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice

• normal pulmonary infiltration of CD4+ CD3+ T cells and Treg cells 21 days after injection of LLC tumor cells

• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice

• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice

• normal CD8+ T cell activation, proliferation and migration in lungs and spleen after injection of LLC tumor cells

decreased CD8-positive, alpha-beta T cell number ( J:298188 )

• reduced percentage of CD8+ T cells among CD3+ cells in spleen and lungs 21 days after injection of LLC tumor cells and in lungs 35 days after injection of B16K1 tumor cells

• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice

• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice

• normal apoptosis rate of CD8+ T cells among CD3+ cells in spleen in tumor-bearing mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:298188 )

N • normal thymocyte development, weight and morphology at age 8 weeks

reproductive system

reproductive system phenotype ( J:298188 )

N • fertile and normal litter size

growth/size/body

growth/size/body region phenotype ( J:298188 )

N • normal postnatal weight gain