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Phenotypes Associated with This Genotype
Genotype
MGI:6488580
Allelic
Composition		 Adam28tm1.2Dica/Adam28tm1.2Dica
Genetic
Background		 CJRj.129-Adam28tm1.2Dica
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam28tm1.2Dica mutation (0 available); any Adam28 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of induced tumors ( J:298188 )
• increased tumor density in lungs after injection of mammary 4T1 cells

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:298188 )
• reduced percentage of CD8+ T cells among CD3+ cells in lungs 14 days after injection of mammary 4T1 cells
• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice
• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice

immune system
decreased CD8-positive, alpha-beta T cell number ( J:298188 )
• reduced percentage of CD8+ T cells among CD3+ cells in lungs 14 days after injection of mammary 4T1 cells
• reduced percentage of CD8+ T cells among CD3+ cells in spleen in tumor-free mice
• normal percentage of CD8+ T cells among CD3+ cells in lungs in tumor-free mice

reproductive system
reproductive system phenotype ( J:298188 )
N
• fertile and normal litter size

growth/size/body
growth/size/body region phenotype ( J:298188 )
N
• normal postnatal weight gain

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory