Phenotypes Associated with This Genotype

Genotype
MGI:6492974

• Allelic Composition: Ndc80^em1(IMPC)J/Ndc80^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Ndc80^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Ndc80

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ndc80^em1(IMPC)J/Ndc80^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida and are dead after 72 hours in culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that blastocysts fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• early blastocysts are present in approximate Mendelian ratios at E3.5 (31% versus expected 25%, n=32); no homozygous embryos can be recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo