Phenotypes Associated with This Genotype

Genotype
MGI:6500742

• Allelic Composition: Ace2^em1Cya/Y
• Genetic Background: C57BL/6J-Ace2^em1Cya/Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

intestinal inflammation ( J:299383 )

• mice with DSS-induced inflammatory bowel disease show increased infiltration of inflammatory cells

increased susceptibility to induced colitis ( J:299383 )

• mice exhibit increased susceptibility to inflammatory bowel disease (IBD), with mice showing more pronounced weight loss, earlier bloody feces and higher feces album level, increased destruction of intestinal architecture and crypts loss, increased infiltration of inflammatory cells, obvious edema and reduction in colon length after dextran sodium sulfate (DSS) administration

digestive/alimentary system

abnormal feces composition ( J:299383 )

• mice show higher feces album level when treated with DSS to induce IBD

melena ( J:299383 )

• mice with DSS-induced IBD show earlier blood feces than in wild-type mice

abnormal intestine morphology ( J:299383 )

• mice show increased destruction of intestinal architecture and crypt loss when treated with DSS to induce IBD

decreased colon length ( J:299383 )

• mice with DSS-induced IBD show a reduction in colon length

intestinal edema ( J:299383 )

• mice with DSS-induced IBD show obvious edema

abnormal intestine physiology ( J:299383 )

• ATP-induced intracellular calcium concentration is higher in intestinal organoids, indicating a calcium overload

• permeability of intestinal organoids is increased

impaired intestine regeneration ( J:299383 )

• mice show a slower regeneration of intestinal organoids than in wild-type mice, showing a smaller size and slowed differentiation

intestinal inflammation ( J:299383 )

• mice with DSS-induced inflammatory bowel disease show increased infiltration of inflammatory cells

increased susceptibility to induced colitis ( J:299383 )

• mice exhibit increased susceptibility to inflammatory bowel disease (IBD), with mice showing more pronounced weight loss, earlier bloody feces and higher feces album level, increased destruction of intestinal architecture and crypts loss, increased infiltration of inflammatory cells, obvious edema and reduction in colon length after dextran sodium sulfate (DSS) administration

growth/size/body

increased susceptibility to weight loss ( J:299383 )

• mice show increased weight loss when treated with dextran sodium sulfate to induce IBD

homeostasis/metabolism

intestinal edema ( J:299383 )

• mice with DSS-induced IBD show obvious edema

cellular

oxidative stress ( J:299383 )

• reactive oxygen species (ROS) production is elevated in intestinal organoids