Phenotypes Associated with This Genotype

Genotype
MGI:6501042

• Allelic Composition: Prdm9^tm1Ymat/Prdm9^tm1Ymat
• Genetic Background: B6.129P2-Prdm9^tm1Ymat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal chiasmata formation ( J:299008 )

♀ • approximately 4% of P0 metaphase oocytes have a full complement of crossovers

abnormal chromosomal synapsis ( J:296124 )

♂ • >98% of pachytene cells fail to properly synapse at least one pair of chromosomes

♂ • 63.2% of (pseudo)pachytene cells show mispairing of non-homologous chromosomes in a branched 'tangled' structure

abnormal female meiosis ( J:299008 )

♀

abnormal female meiosis I arrest ( J:299008 )

♀ • P0 oocytes have widespread asynapsis

female infertility ( J:299008 )

♀ • females fail to reproduce, but when Chek2 is also absent then some fertility is recovered

male infertility ( J:296124 )

♂

cellular

abnormal chiasmata formation ( J:299008 )

♀ • approximately 4% of P0 metaphase oocytes have a full complement of crossovers

abnormal chromosomal synapsis ( J:296124 )

♂ • >98% of pachytene cells fail to properly synapse at least one pair of chromosomes

♂ • 63.2% of (pseudo)pachytene cells show mispairing of non-homologous chromosomes in a branched 'tangled' structure

abnormal female meiosis ( J:299008 )

♀

abnormal female meiosis I arrest ( J:299008 )

♀ • P0 oocytes have widespread asynapsis

abnormal double-strand DNA break repair ( J:296124 )

♂ • increased DMC1 foci count from zygotene onwards indicating delayed repair of DSBs

♂ • increased number of RAD51 foci in (pseudo)-pachytene cells

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:296124 )

♂ • increased DMC1 foci count from zygotene onwards indicating delayed repair of DSBs

♂ • increased number of RAD51 foci in (pseudo)-pachytene cells