Phenotypes Associated with This Genotype

Genotype
MGI:6501209

• Allelic Composition: Atrip^tm1.1Pof/Atrip^tm1.1Pof; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased dorsal striatum total cell area ( J:299031 )

hippocampus hypoplasia ( J:299031 )

• severe developmental growth impairment at age P7

decreased cerebral cortex total cell area ( J:299031 )

• severe developmental growth impairment at age P7

cerebellum hypoplasia ( J:299031 )

• severe developmental growth impairment at age P7

vision/eye

increased lens epithelium apoptosis ( J:299031 )

• in E17.5 embryos

• dysregulated DNA damage response (DDR)

abnormal lens epithelium morphology ( J:299031 )

• abnormal organization of transition zone at age P7

abnormal lens fiber morphology ( J:299031 )

• lack of organelle-free zone (OFZ) in fiber cells at age P7

microphthalmia ( J:299031 )

• ~50% reduction in eye volume at age P7

mortality/aging

mortality/aging ( J:299031 )

N • viable; mice born at expected Mendelian ratio

preweaning lethality, complete penetrance ( J:299031 )

• mice die around age P9

cellular

abnormal cell physiology ( J:299031 )

• dysregulated DNA damage response (DDR)

• normal cell cycle and proportion of mitotic cells of lens progenitor cells in E17.5 embryos

abnormal mitosis ( J:299031 )

• increased number of mitotic defects in lens progenitor cells in E15.5 embryos

increased lens epithelium apoptosis ( J:299031 )

• in E17.5 embryos

• dysregulated DNA damage response (DDR)

growth/size/body

decreased birth weight ( J:299031 )

• lower body mass at birth

decreased body weight ( J:299031 )

• at age P13

microcephaly ( J:299031 )