Phenotypes Associated with This Genotype

Genotype
MGI:6501211

• Allelic Composition: Atrip^tm1.1Pof/Atrip^tm1.1Pof; Tg(Nes-cre)1Kln/0; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

microphthalmia ( J:299031 )

• ~50% reduction in eye volume at age P7

growth/size/body

decreased body weight ( J:299031 )

• at age P13

microcephaly ( J:299031 )

• at age P13

cellular

abnormal cell physiology ( J:299031 )

• dysregulated DNA damage response (DDR) of lens progenitor cells in E15.5 embryos

• normal cell cycle and proportion of mitotic cells of lens progenitor cells in E15.5 embryos

• no lens epithelium apoptosis in E15.5 embryos

abnormal mitosis ( J:299031 )

• increased number of mitotic defects in lens progenitor cells in E15.5 embryos