Phenotypes Associated with This Genotype

Genotype
MGI:6506053

• Allelic Composition: Gsg1l^tm1.2Tern/Gsg1l^tm1.2Tern
• Genetic Background: C57BL/6J-Gsg1l^tm1.2Tern

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:301313 )

• increased susceptibility to kainate-induced seizures: higher mortality rates and higher morbidity scores

abnormal action potential ( J:301313 )

• 4-fold increase in number of AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons exhibiting spontaneous action potential spikes

• reduced input resistance in AD/AV neurons

• normal resting membrane potential, rheobase and neuronal firing rate in AD/AV neurons

abnormal synaptic transmission ( J:301313 )

• reduced input resistance in AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons leading to increased synaptic activity

abnormal excitatory postsynaptic currents ( J:301313 )

• reduced asynchronous qEPSC decay time at C-T synapses

• increased asynchronous quantal EPSC (qEPSC) amplitude, higher frequency and accelerated kinetics at corticothalamic (C-T) synapses

• increased AMPA-type ionotropic glutamate receptor (AMPAR)-mediated miniature EPSC (mEPSC) amplitude in subset of AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons

• normal mEPSC frequencies

• normal asynchronous qEPSC rise time at C-T synapses

• normal asynchronous qEPSC amplitude, frequency and kinetics at mammillothalamic (M-T) and subiculum-thalamic (S-T) synapses

increased excitatory postsynaptic current amplitude ( J:301313 )

• increased asynchronous quantal EPSC (qEPSC) amplitude and higher frequencies

• increased AMPA-type ionotropic glutamate receptor (AMPAR)-mediated spontaneous EPSC (sEPSC) amplitude and frequency in AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons

short excitatory postsynaptic current decay time ( J:301313 )

• reduced asynchronous quantal EPSC (qEPSC) decay time

abnormal miniature excitatory postsynaptic currents ( J:301313 )

• increased AMPA-type ionotropic glutamate receptor (AMPAR)-mediated miniature EPSC (mEPSC) amplitude in subset of AD/AV (anterodorsal nucleus and anteroventral nucleus in anterior thalamus (AT)) neurons

• normal mEPSC frequencies

behavior/neurological

abnormal behavior ( J:301313 )

• lower novel object recognition index during test phase

• normal behavior in rotarod and elevated zero maze tests and normal grip strength and gait

increased susceptibility to pharmacologically induced seizures ( J:301313 )

• increased susceptibility to kainate-induced seizures: higher mortality rates and higher morbidity scores

abnormal response to novel object ( J:301313 )

• lower novel object recognition index during test phase