Phenotypes Associated with This Genotype

Genotype
MGI:6508531

• Allelic Composition: Cd4^{tm1(cre/ERT2)Thbu}/Cd4⁺; Gfm1^{tm1c(EUCOMM)Wtsi}/Gfm1^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 17 cell differentiation ( J:302272 )

• differentiation of tamoxifen-treated nave T cells under Th17 cell-skewing conditions yields a reduced frequency of IL-17 expressing cells

increased CD8-positive, alpha-beta T cell number ( J:302272 )

• tamoxifen-induced mice show a modest increase in the proportion of single-positive CD8+ population in the thymus

increased single-positive T cell number ( J:302272 )

• tamoxifen-induced mice show a modest increase in the proportion of single-positive CD8+ population in the thymus

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:302272 )

• tamoxifen-treated mice show significant protection from the development of experimental autoimmune encephalomyelitis (EAE), with mice showing lower numbers and percentages of MOG-specific IL-17 and IFN-gamma-producing Th cells in the central nervous system

hematopoietic system

abnormal T-helper 17 cell differentiation ( J:302272 )

• differentiation of tamoxifen-treated nave T cells under Th17 cell-skewing conditions yields a reduced frequency of IL-17 expressing cells

increased CD8-positive, alpha-beta T cell number ( J:302272 )

• tamoxifen-induced mice show a modest increase in the proportion of single-positive CD8+ population in the thymus

increased single-positive T cell number ( J:302272 )

• tamoxifen-induced mice show a modest increase in the proportion of single-positive CD8+ population in the thymus