Phenotypes Associated with This Genotype

Genotype
MGI:6514417

• Allelic Composition: Lypla1^tm1Sem/Lypla1^tm1Sem; Tg(Tek-cre)12Flv/0
• Genetic Background: B6(Cg)-Lypla1^tm1Sem Tg(Tek-cre)12Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta morphology ( J:302677 )

• aortas have increased soluble and insoluble fibronectin

abnormal physiological neovascularization ( J:302677 )

• mice subjected to femoral artery ligation (model of peripheral artery disease) show decreased restoration of limb perfusion, with reduced vessel area and smaller lumen size of arteries, indicating decreased arteriogenesis

• mice subjected to femoral artery ligation show decreased pericyte coverage of microvascular networks, indicating decreased angiogenesis

• 2 weeks after femoral artery ligation, fibronectin is increased in the intima, but not the media, of lower extremity arteries

abnormal vascular endothelial cell physiology ( J:302677 )

• primary endothelial cells exhibit increased F-actin stress fibers, increased cell-matrix adhesions, and increased cell spreading

• adherens junctions are reduced in confluent endothelial cells

• the ratio of insoluble/soluble fibronectin is decreased in aortic endothelial cells and turnover of fibronectin is decreased, indicating decreased maturation of fibronectin matrix

abnormal vascular endothelial cell adhesion ( J:302677 )

• primary endothelial cells coated on microbeads embedded in fibrin gel give rise to tree-like structures with broken branches and isolated cells unlike control cells, indicating altered cell adhesion

cellular

abnormal vascular endothelial cell adhesion ( J:302677 )

• primary endothelial cells coated on microbeads embedded in fibrin gel give rise to tree-like structures with broken branches and isolated cells unlike control cells, indicating altered cell adhesion