Phenotypes Associated with This Genotype

Genotype
MGI:6514876

• Allelic Composition: Ace2^em2(ACE2)Gpt/Y
• Genetic Background: C57BL/6JGpt-Ace2^em2(ACE2)Gpt/Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

lung inflammation ( J:302150 )

♂ • mice infected with SARS-CoV-2 exhibit severe lung lesions as shown by infiltration of inflammatory cells and thickened alveolar septa

increased susceptibility to Coronaviridae infection ( J:302150 )

♂ • mice are susceptible to infection with SARS-CoV-2 , showing viral RNA in the lungs and severe lung lesions, infiltration of inflammatory cells, and thickened alveolar septa

♂ • treatment with Nb(15)-Nb(H)-Nb(15), a heterotrimer of neutralizing nanobodies derived from an alpaca immunized with SARS-CoV-2 spike glycoprotein constructed to be bispecific for human serum albumin and RBD of SARS-CoV-2, 24 hours before or 1 hour after SARS-CoV-2 viral challenge provides complete protection against infection and significantly inhibits viral replication when administered 24 hours post infection

respiratory system

lung inflammation ( J:302150 )

♂ • mice infected with SARS-CoV-2 exhibit severe lung lesions as shown by infiltration of inflammatory cells and thickened alveolar septa

growth/size/body

increased susceptibility to weight loss ( J:302150 )

♂ • mice infected with SARS-CoV-2 show weight loss