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Phenotypes Associated with This Genotype
Genotype
MGI:6712734
Allelic
Composition		 Trp53tm1Tyj/Trp53tm1Tyj
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (4 available); any Commd10 mutation (25 available)
Riok2tm1c(KOMP)Wtsi mutation (0 available); any Riok2 mutation (33 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (244 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:305794 )
N
• the increase in IL-22 secretion seen in in vitro polarized TH22 cells in single conditional Riok2 heterozygotes is blunted

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory