Phenotypes Associated with This Genotype

Genotype
MGI:6715307

• Allelic Composition: Mki67^em1Dfis/Mki67^em1Dfis
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:304800 )

• 16 weeks after AOM-DSS treatment, homozygotes exhibit no macroscopic intestinal neoplastic lesions, unlike similarly treated wild-type and heterozygous mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:304800 )

• 16 weeks after AOM-DSS treatment, homozygotes exhibit no macroscopic intestinal neoplastic lesions, unlike similarly treated wild-type and heterozygous mice

immune system

immune system phenotype ( J:304800 )

N • during induction of colon tumors by azoxymethane/dextran sodium sulfate (AOM-DSS) treatment, DSS-treated homozygotes show a similar decrease in body weight and a typical DSS-induced colitis (with increased numbers of immune cells in the lamina propria, moderate crypt cells damage, and hyperplasia) relative to heterozygous controls