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Phenotypes Associated with This Genotype
Genotype
MGI:6715308
Allelic
Composition		 Apctm1Cip/Apc+
Mki67em1Dfis/Mki67em1Dfis
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Cip mutation (0 available); any Apc mutation (157 available)
Mki67em1Dfis mutation (0 available); any Mki67 mutation (145 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased incidence of tumors by chemical induction ( J:304800 )
• 6 months after induction of colon tumors by AOM-DSS treatment, mice exhibit a significant decrease both in the number of neoplastic lesions/mouse and in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67em1Dfis and Apctm1Cip
decreased tumor growth/size ( J:304800 )
• 6 months after AOM-DSS treatment, mice exhibit a significant decrease in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67em1Dfis and Apctm1Cip

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:304800 )
• 6 months after induction of colon tumors by AOM-DSS treatment, mice exhibit a significant decrease both in the number of neoplastic lesions/mouse and in total lesion area (mm2) relative to similarly treated mice heterozygous for Mki67em1Dfis and Apctm1Cip

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory