Phenotypes Associated with This Genotype

Genotype
MGI:6728084

• Allelic Composition: Klhl17^em1Yph/Klhl17⁺
• Genetic Background: C57BL/6-Klhl17^em1Yph

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to social novelty ( J:308069 )

• mice show reduced interaction with unfamiliar mice in reciprocal social interaction

increased vertical activity ( J:308069 )

• mice exhibit more frequent rearing behaviors in the open field

increased locomotor activity ( J:308069 )

• mice exhibit longer moving distances in the open field

• however, mice show no differences from wild-type in the elevated plus maze

nervous system

abnormal dendritic spine morphology ( J:308069 )

• width of dendritic spine heads of neurons is reduced

• however, spine density and length are not altered

increased miniature excitatory postsynaptic current amplitude ( J:308069 )

• mEPSC amplitude of hippocampal neurons is slightly increased

• however, mEPSC frequency is normal