Analysis Tools
behavior/neurological
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• mice exhibit increased susceptibility to hyperthermia-induced seizure, with mice reaching phase 4 (tonic convulsions with loss of consciousness) seizures at lower core temperature than wild-type mice and heat exposure causing their core temperature to increase more rapidly
• however, merely raising the ambient temperature to 37 degrees Celsius is not sufficient to induce seizures
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homeostasis/metabolism
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• P11 mice exhibit lower core temperature at ambient temperature of 22 or 30 degrees C, but core temperature is comparable to wild-type controls when the ambient temperature is held at 37 degrees C and during the following recovery period at 22 degrees C, indicating that pups experience a more rapid increase of core temperature than wild-type littermates when the ambient temperature is raised from 30 degrees C to 37 degrees C
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nervous system
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• mice exhibit increased susceptibility to hyperthermia-induced seizure, with mice reaching phase 4 (tonic convulsions with loss of consciousness) seizures at lower core temperature than wild-type mice and heat exposure causing their core temperature to increase more rapidly
• however, merely raising the ambient temperature to 37 degrees Celsius is not sufficient to induce seizures
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