Phenotypes Associated with This Genotype

Genotype
MGI:6790233

• Allelic Composition: Ano3^tm1.1Lyj/Ano3^tm1.1Lyj; Ptgds^{tm1.1(cre)Gvn}/Ptgds⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

environmentally induced seizures ( J:310618 )

• P11 pups exhibit a greater susceptibility to hyperthermia-induced seizures

• however, mice show comparable susceptibility to chemoconvulsant-induced seizures

homeostasis/metabolism

abnormal body temperature homeostasis ( J:310618 )

• P11 mice exhibit a more rapid core temperature increase upon heat exposure

• P11 mice exhibit lower core temperature at ambient temperature of 22 or 30 degrees Celsius, but core temperature is comparable to wild-type controls when the ambient temperature is held at 37 degrees C

• the slopes of core temperature change with ambient temperature manipulation differs from controls

nervous system

environmentally induced seizures ( J:310618 )

• P11 pups exhibit a greater susceptibility to hyperthermia-induced seizures

• however, mice show comparable susceptibility to chemoconvulsant-induced seizures