Phenotypes Associated with This Genotype

Genotype
MGI:6790420

• Allelic Composition: Irgm2^em1Myam/Irgm2^em1Myam
• Genetic Background: C57BL/6-Irgm2^em1Myam

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to parasitic infection induced morbidity/mortality ( J:308470 )

• T. gondii infected mice die after 9 days unlike wild-type mice

immune system

increased susceptibility to parasitic infection ( J:308470 )

• although not as severe as in Irgm1/Igtp double or triple knock-out mice, bone marrow-derived macrophages, bone marrow-derived dendritic cells, and mouse embryonic fibroblast exhibit impaired IFN-gamma-induced reduction of T. gondii numbers compared with wild-type cells

• T. gondii infected mice die after 9 days unlike wild-type mice

• however, Toxoplasma localization to parasitophorous vacuole membranes is normal

increased susceptibility to parasitic infection induced morbidity/mortality ( J:308470 )

• T. gondii infected mice die after 9 days unlike wild-type mice