Phenotypes Associated with This Genotype

Genotype
MGI:6828947

• Allelic Composition: Cirbil^em1Cya/Cirbil^em1Cya
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased cardiac muscle contractility ( J:301260 )

• following ischemia/reperfusion injury

• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response

increased myocardial infarct size ( J:301260 )

• following ischemia/reperfusion injury

• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response

homeostasis/metabolism

increased myocardial infarct size ( J:301260 )

• following ischemia/reperfusion injury

• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response

increased circulating lactate dehydrogenase level ( J:301260 )

• more than in control mice following ischemia/reperfusion injury

cellular

increased cardiomyocyte apoptosis ( J:301260 )

• following ischemia/reperfusion injury

• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response

muscle

decreased cardiac muscle contractility ( J:301260 )

• following ischemia/reperfusion injury

• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response

increased cardiomyocyte apoptosis ( J:301260 )

• following ischemia/reperfusion injury

• however, knockdown of Bclaf1 via adenoviral expressing CRISPR-targeting Bclaf1 restores wild-type response