Phenotypes Associated with This Genotype

Genotype
MGI:6835667

• Allelic Composition: Tsnax^{Gt(S21-6D1)Sor}/Tsnax^{Gt(S21-6D1)Sor}
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to ionizing radiation ( J:313427 )

• UV-C-treated mouse embryonic fibroblasts (MEFs) exhibit increased DNA damage and decreased viability compared with wild-type cells

• in MEFs treated with 2 Gy gamma-ray irradiation

• treatment with an adenovirus expressing the endogenous protein lacking the nuclear localization sequence fails to rescue cell death

• however, treatment with an adenovirus expressing the wild-type protein exhibit rescued cell death

increased fibroblast apoptosis ( J:313427 )

• in UV-C-treated mouse embryonic fibroblasts associated with impaired DNA repair

abnormal DNA repair ( J:313427 )

• in UV-C-treated mouse embryonic

homeostasis/metabolism

abnormal DNA repair ( J:313427 )

• in UV-C-treated mouse embryonic